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Stereoselective 1,6-Conjugate Addition/Annulation of para -Quinone Methides with Vinyl Epoxides/Cyclopropanes

2016; American Chemical Society; Volume: 6; Issue: 10 Linguagem: Inglês

10.1021/acscatal.6b01845

2155-5435

Chao Ma, Yuan Huang, Yu Zhao,

Chemical Synthesis and Reactions

Here, we present an unprecedented formal [3 + 2] cycloaddition of para-quinone methides with vinyl epoxides/cyclopropanes to deliver a wide range of spiro[4.5]decanes in high efficiency and stereoselectivity. The commercial availability of the catalysts and reagents, together with the convenient procedure, makes it an attractive method in asymmetric synthesis.