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Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

1992; Springer Nature; Volume: 45; Issue: 12 Linguagem: Inglês

10.7164/antibiotics.45.1853

1881-1469

Robert E. Schwartz, David F. Sesin, H Joshua, Kenneth E. Wilson, AUGUST J. KEMPF, KENT A. GOKLEN, Daniel Kuehner, P. Gailliot, CAROLYN GLEASON, Raymond F. White, Edward Inamine, Gerald F. Bills, Peter Salmon, LAURETTA ZITANO,

Synthesis and Catalytic Reactions

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688, 786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671, 329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneurnocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.