Combination therapeutics in complex diseases
2016; Wiley; Volume: 20; Issue: 12 Linguagem: Inglês
10.1111/jcmm.12930
ISSN1582-4934
AutoresBing He, Cheng Lü, Guang Zheng, Xiaojuan He, Maolin Wang, Chen Gao, Ge Zhang, Aiping Lü,
Tópico(s)Protein Degradation and Inhibitors
ResumoAbstract The biological redundancies in molecular networks of complex diseases limit the efficacy of many single drug therapies. Combination therapeutics, as a common therapeutic method, involve pharmacological intervention using several drugs that interact with multiple targets in the molecular networks of diseases and may achieve better efficacy and/or less toxicity than monotherapy in practice. The development of combination therapeutics is complicated by several critical issues, including identifying multiple targets, targeting strategies and the drug combination. This review summarizes the current achievements in combination therapeutics, with a particular emphasis on the efforts to develop combination therapeutics for complex diseases.
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