Portal de Periódicos da CAPES

Proteína C-reativa como biomarcador inflamatório e fatores associados em diabéticos tipo 2 atendidos na rede pública de saúde

2016; Volume: 36; Issue: 2 Linguagem: Português

1989-208X

Marcela de Albuquerque Melo, Rafael Miranda Tassitano, Marina de Moraes Vasconcelos Petribú, Eduíla Maria Couto Santos, Raquel Araújo de Santana, Florisbela de Arruda Câmara e Siqueira Campos,

Healthcare Regulation

EnglishIntroduction: Diabetes is a global epidemic that increases the risk of circulatory events and constitutes a considerable challenge to healthcare services. Objective: Determine levels of high sensitivity C-reactive protein levels and associated factors in patients with diabetes in the municipality of Vitoria de Santo Antao, Brazil. Methods: A population-based, cross-sectional study was conducted from July to October 2011. Socio-demographic, lifestyle, clinical, anthropometric and biochemical variables were analyzed and associations with high sensitivity C-reactive protein levels were determined. Statistical analysis was performed with the aid of the Predictive Analytics Software, version 13.00, with a 5% level of significance. Results: The sample comprised 409 individuals, 73.1% of whom were female. Age ranged from 20 to 90 years (mean: 61.00 ± 11.62 years) and older adults accounted for the largest proportion of the sample (56.2%). The body mass index demonstrated that 75.2% had excess weight. The waist-to-hip ratio, waistto-height ratio, conicity index and waist circumference revealed obesity rates of 65.4%, 90.27%, 89.0% and 58.4%, respectively. A total of 53.2% had high sensitivity C-reactive protein levels (> 0.3 mg/L). Moreover, sex, level of schooling, fasting blood sugar, high density lipoprotein cholesterol, waist-to-height ratio and waist circumference were significantly associated with inflammation after controlling for confounding variables. Discussion: The present results suggest that maintaining a fasting blood sugar level below 100 mg/dl and a good HDL-c level as well as avoiding central obesity can have a protective effect against the occurrence of chronic inflammation in patients with diabetes. Conclusion: High sensitivity C-reactive protein levels were high in the majority of patients studied and were associated with the female sex, abdominal obesity, low HDL-c levels, a low level of schooling and high blood sugar levels portuguesIntroducao: O Diabetes configura-se hoje como uma epidemia mundial, traduzindo-se em grande desafio para os sistemas de saude e favorece o risco de eventos circulatorios. Objetivo: Determinar os niveis de Proteina C-Reativa ultrassensivel (PCR-us) e fatores associados em diabeticos do municipio de Vitoria de Santo Antao, PE, Brasil. Metodos: Estudo transversal, de base populacional, realizado entre julho e outubro de 2011. Foram avaliadas variaveis socio-demograficas, estilo de vida, clinicas, antropometricas e bioquimicas, as quais foram associadas aos niveis PCR-us. Os dados foram analisados no programa Predictive Analytics Software (PASW), versao 13.00; nivel de significância de 5%. Resultados: A amostra foi constituida por 409 individuos, sendo 73,1% do sexo feminino. A idade variou entre 20 e 90 anos, com media de 61,00 ± 11,62 anos; com maior proporcao (56,2%) de idosos. O Indice de massa corporal (IMC) mostrou 75,2% de excesso de peso. Enquanto Razao Cintura Quadril (RCQ), Razao Cintura Estatura (RCEst), Indice de Conicidade (IC) e Circunferencia da Cintura (CC) revelaram 65,4%, 90,27%, 89,0% e 58,4% de obesidade central na amostra, respectivamente. Quanto a PCR-us, 53,2% dos participantes mostraram elevado nivel serico (>0,3 mg/L); e as variaveis associadas a ocorrencia de inflamacao foram: sexo, grau de escolaridade, Glicemia de Jejum, Lipoproteina de alta densidade (HDL-c), RCEst e CC, apos ajuste para variaveis de confusao. Discussao: Os resultados sugerem que manter uma GJ abaixo de 100mg/dl, um bom nivel de HDL-c e evitar a obesidade central poderia ter um efeito protetor contra a ocorrencia de inflamacao cronica em diabeticos. Conclusao: Os niveis de PCR-us mostraram-se elevados na maioria dos pacientes estudados e estao associados a tais niveis: o sexo feminino, a obesi- dade abdominal, baixos niveis de HDL-c, escolaridade e glicemia elevadas.