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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

2016; Public Library of Science; Volume: 13; Issue: 8 Linguagem: Inglês

10.1371/journal.pmed.1002105

1549-1676

Yan Guo, Shaneda Warren Andersen, Xiao‐Ou Shu, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Montserrat García‐Closas, Roger L. Milne, Marjanka K. Schmidt, Jenny Chang‐Claude, Alison M. Dunning, Stig E. Bojesen, Habibul Ahsan, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, Natalia Bogdanova, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Graham Casey, Georgia Chenevix‐Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Martine Dumont, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Marilie D. Gammon, Graham G. Giles, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Farzana Jasmine, Mark A. Jenkins, Esther M. John, Nichola Johnson, Michael E. Jones, Maria Kabisch, Muhammad G. Kibriya, Julia A. Knight, Linetta B. Koppert, Veli‐Matti Kosma, Vessela N. Kristensen, Loı̈c Le Marchand, Eunjung Lee, Jingmei Li, Annika Lindblom, Robert Luben, Jan Lubiński, Kathi Malone, Graham J. Mann, Sara Margolin, Frederik Marmé, Catriona McLean, Hanne Meijers‐Heijboer, Alfons Meindl, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Janet E. Olson, José Ignacio Arias Pérez, Barbara Perkins, Paolo Peterlongo, Kelly‐Anne Phillips, Katri Pylkäs, Anja Rudolph, Regina M. Santella, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Martha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Amanda E. Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Giske Ursin, Rob B. van der Luijt, Senno Verhoef, Alice S. Whittemore, Robert Winqvist, Hui Zhao, Shilin Zhao, Per Hall, Jacques Simard, Peter Kraft, Paul D.P. Pharoah, David J. Hunter, Douglas F. Easton, Wei Zheng,

Nutritional Studies and Diet

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.