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Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

2016; Dove Medical Press; Volume: Volume 10; Linguagem: Inglês

10.2147/dddt.s110529

1177-8881

Mustafa Arslan, Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Ayşe Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Ayşegül Küçük,

Electrolyte and hormonal disorders

Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. Materials and methods: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period. Effects of agents on renal, lung, and skeletal muscle (gastrocnemius) tissue specimens were examined. Results: Renal medullary congestion, cytoplasmic swelling, and mean tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/R-only group ( P <0.0001, P =0.015, and P <0.01, respectively). Polymorphonuclear leukocyte infiltration, pulmonary partial destruction, consolidation, alveolar edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups ( P =0.017 and P =0.001; P <0.01 and P <0.0001). Polymorphonuclear leukocyte infiltration scores in skeletal muscle tissue were significantly lower in the iloprost-treated group than the scores found in the nontreated I/R group ( P <0.0001). Conclusion: Alprostadil and iloprost significantly reduce lung tissue I/R injury. Alprostadil has more prominent protective effects against renal I/R injury, while iloprost is superior in terms of protecting the skeletal muscle tissue against I/R injury. Keywords: alprostadil, iloprost, ischemia reperfusion injury, rat, renal, lung, skeletal muscle