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Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study

2016; Taylor & Francis; Volume: 58; Issue: 4 Linguagem: Inglês

10.1080/10428194.2016.1219904

1042-8194

Jorge Alfonso Martín‐Trejo, Juan Carlos Núñez-Enríquez, Arturo Fajardo‐Gutiérrez, Aurora Medina‐Sansón, Janet Flores‐Lujano, Elva Jiménez‐Hernández, Raquel Amador‐Sánchez, José Gabriel Peñaloza‐González, Francisco Javier Álvarez Rodríguez, Victoria Bolea-Murga, Rosa Martha Espinosa‐Elizondo, José de Diego Flores-Chapa, María Luisa Pérez‐Saldivar, Maria del Carmen Rodrı́guez-Zepeda, Elisa Dorantes‐Acosta, Nora Nancy Núñez-Villegas, Martha Margarita Velázquez‐Aviña, José Refugio Torres‐Nava, Nancy Carolina Reyes-Zepeda, César González-Bonilla, Luz Victoria Flores‐Villegas, Angélica Rangel-López, Roberto Rivera‐Luna, Rogelio Paredes‐Aguilera, Rocío Cárdenas‐Cardós, Armando Martínez-Ávalos, Ana Elena Gil-Hernández, David Aldebarán Duarte-Rodríguez, Juan Manuel Mejίa‐Aranguré,

Nutrition and Health in Aging

The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient's age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08–4.01) was observed in the group of malnourished children with a high-risk ALL.