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Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection

2016; Elsevier BV; Volume: 101; Linguagem: Inglês

10.1016/j.tube.2016.07.018

1873-281X

Catherine Riou, Rubina Bunjun, Tracey L. Müller, Agano Kiravu, Zekarias Ginbot, Tolu Oni, René Goliath, Robert J. Wilkinson, Wendy A. Burgers,

HIV Research and Treatment

HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-γ single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-γ+IL-2+TNF-α+) remained unchanged. Moreover, the proportion of IFN-γ single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity.