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Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity.

1987; Springer Nature; Volume: 40; Issue: 5 Linguagem: Inglês

10.7164/antibiotics.40.567

1881-1469

Robert J. Theriault, James P. Karwowski, MARIANNA JACKSON, R. L. Girolami, GABRIELA N. SUNGA, C Vojtko, L.J. Coen,

Plant Pathogens and Fungal Diseases

A complex of 18-membered macrolide antibiotics has been discovered in the fermentation broth of strain AB718C-41. The producing culture, isolated from a soil sample collected in Hamden, Connecticut, was identified as a strain of Dactylosporangium aurantiacum and was designated D. aurantiacum subsp. hamdenensis subsp. nov. The antibiotic complex was produced in a New Brunswick 150-liter fermentor using a medium consisting of glucose, soybean oil, soybean flour, beef extract and inorganic salts. Several of the antibiotics were active against sensitive and multiple antibiotic-resistant strains of pathogenic Gram-positive bacteria.