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The Primary Outcome Fails — What Next?

2016; Massachusetts Medical Society; Volume: 375; Issue: 9 Linguagem: Inglês

10.1056/nejmra1510064

1533-4406

Stuart J. Pocock, Gregg W. Stone,

Meta-analysis and systematic reviews

When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information still be derived from it? This review article addresses that question.