Tandem Difluoroalkylation‐Arylation of Enamides Catalyzed by Nickel
2016; Wiley; Volume: 55; Issue: 40 Linguagem: Inglês
10.1002/anie.201606458
ISSN1521-3773
AutoresJiwei Gu, Qiao‐Qiao Min, Ling‐Chao Yu, Xingang Zhang,
Tópico(s)Cyclopropane Reaction Mechanisms
ResumoAbstract A nickel‐catalyzed three‐component reaction for the synthesis of difluoroalkylated compounds through tandem difluoroalkylation‐arylation of enamides has been developed. The reaction tolerates a variety of arylboronic acids and widely available difluoroalkyl bromides, and even the relatively inert substrate chlorodifluoroacetate. The significant advantages of this protocol are the low‐cost nickel catalyst, synthetic convenience, excellent functional‐group compatibility and high reaction efficiency.
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