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Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

2016; Oxford University Press; Volume: 3; Issue: 4 Linguagem: Inglês

10.1093/ofid/ofw175

2328-8957

Yong‐Qiang Deng, Na-Na Zhang, Chun-Feng Li, Min Tian, Jianan Hao, Xu-Ping Xie, Pei‐Yong Shi, Cheng‐Feng Qin,

Viral Infections and Vectors

Abstract The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.