Aptamer-functionalized graphene-gold nanocomposites for label-free detection of dielectrophoretic-enriched neuropeptide Y
2016; Elsevier BV; Volume: 72; Linguagem: Inglês
10.1016/j.elecom.2016.09.017
ISSN1873-1902
AutoresRenny Edwin Fernandez, Bankim J. Sanghavi, Vahid Farmehini, Jorge L. Chávez, Joshua A. Hagen, Nancy Kelley‐Loughnane, Chia‐Fu Chou, Nathan S. Swami,
Tópico(s)Graphene research and applications
ResumoWe present an electrokinetically enhanced aptamer sensing platform on a disposable plastic chip for label-free detection of neuropeptide Y (NPY), which is a key neurological biomarker. The sensor consists of aptamer-functionalized graphene-gold nanocomposites (Gr-AuNs) patterned inside a nanoslit that is embossed on cyclic olefin copolymer via nanoimprint lithography. Analyte molecules are dielectrophoretically focused through the nanoslit onto aptamer-immobilized Gr-AuNs for rapid and selective electrochemical detection of NPY at picomolar levels.
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