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BIBTEX RIS

GATA 3 expression in primary vulvar Paget disease: a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia

2016; Wiley; Volume: 70; Issue: 3 Linguagem: Inglês

10.1111/his.13086

1365-2559

Diogo Lago Morbeck, Aline C. Tregnago, Glauco Baiocchi, Carlos Alberto Ricetto Sacomani, Patricia Peresi, Cynthia Aparecida Bueno de Toledo Osório, Luciana Schutz, Stephania Martins Bezerra, Louise De Brot, Isabela Werneck da Cunha,

Urinary and Genital Oncology Studies

Aims GATA 3 has been reported as a specific urothelial marker among organs in the pelvic region, and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA 3 expression in extramammary Paget disease, and to determine whether it can be use to differentiate primary vulvar Paget disease from pagetoid urothelial intraepithelial neoplasia ( PUIN ). We also analysed HER 2 protein expression and HER 2 gene amplification and their roles as prognostic factors in extramammary Paget disease. Methods and results We analysed GATA 3 and HER 2 expression in 11 primary vulvar Paget disease cases and two PUIN cases. All cases showed nuclear expression of GATA 3. Of 13 cases, five were equivocal for HER 2 expression (score 2+) and one was positive (3+). Fluorescence in‐situ hybridization results showed amplification in two of these six cases. Both HER 2 ‐amplified cases were invasive. Conclusion GATA 3 was positive in all extramammary Paget disease cases tested (13 cases), and it has no value for differentiating between primary and secondary vulvar Paget disease from the urological tract. HER 2 amplification might confer an aggressive and invasive pattern in primary vulvar Paget disease, as both amplified cases showed an invasive pattern.