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Solubility of oxcarbazepine in eight solvents within the temperature range T = (288.15–308.15) K

2016; Elsevier BV; Volume: 104; Linguagem: Inglês

10.1016/j.jct.2016.09.011

1096-3626

Kyung‐Wan Nam, Eun-Sol Ha, Jeong-Soo Kim, Do-Hoon Kuk, Dong-Hyeon Ha, Min‐Soo Kim, Cheong‐Weon Cho, Sung‐Joo Hwang,

Chemical and Physical Properties in Aqueous Solutions

In this study, the solubility of oxcarbazepine in pure methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, and tetrahydrofuran was analysed across the temperature range of 288.15–308.15 K under atmospheric pressure by using a solid-liquid equilibrium method. The experimental values obtained data were correlated using the modified Apelblat model at each temperature. The mole fraction solubility of oxcarbazepine in all eight pure solvents increased gradually in a temperature-dependent manner. The highest mole fraction solubility of 3.08 × 10−3 at 308.15 K was observed for tetrahydrofuran, followed by acetone (1.82 × 10−3 at 308.15 K), acetonitrile (1.22 × 10−3 at 308.15 K), methanol (1.11 × 10−3 at 308.15 K), ethanol (6.17 × 10−4 at 308.15 K), 1-butanol (6.17 × 10−4 at 308.15 K), 1-propanol (6.16 × 10−4 at 308.15 K), and 2-propanol (4.13 × 10−4 at 308.15 K). The experimental solubility in all solvents correlated well with that calculated using the modified Apelblat equation across the temperature range of (288.15–308.15) K. Therefore, the experimental solubility and correlation equations established in this study could be useful during the crystallization/purification, pre-formulation, and formulation stages of oxcarbazepine production in laboratories and related industries.