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Supraclavicular and/or celiac lymph node metastases from thoracic esophageal squamous cell carcinoma did not compromise survival following neoadjuvant chemoradiotherapy and surgery

2016; Impact Journals LLC; Volume: 8; Issue: 2 Linguagem: Inglês

10.18632/oncotarget.12200

1949-2553

Won Kyung Cho, Dongryul Oh, Yong Chan Ahn, Young Mog Shim, Jae Ill Zo, Jong‐Mu Sun, Myung‐Ju Ahn, Keunchil Park,

Esophageal and GI Pathology

// Won Kyung Cho 1,* , Dongryul Oh 1,* , Yong Chan Ahn 1 , Young Mog Shim 2 , Jae Ill Zo 2 , Jong-Mu Sun 3 , Myung-Ju Ahn 3 and Keunchil Park 3 1 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea 2 Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea 3 Medicine (Division of Hematology-Oncology), Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea * These authors have equally contributed to this manuscript as the first authors Correspondence to: Yong Chan Ahn, email : // , // Keywords : esophageal cancer, neoadjuvant chemoradiotherapy, supraclavicular lymph node, celiac lymph node, staging Received : May 11, 2016 Accepted : September 16, 2016 Published : September 22, 2016 Abstract This study is to evaluate the prognostic significance of supraclavicular and/or celiac lymph node (LN) metastases in locally advanced thoracic esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (NACRT) and surgery. Among the total 199 patients, 75 (37.7%) had supraclavicular and/or celiac LN metastasis. Surgery was performed following NACRT in 168 patients (84.4%). After the median 18.7 (1.0-147.2) months’ follow-up, 2-year rates of progression-free survival (PFS) and overall survival (OS) in all patients were 48.1% and 65.7%, respectively. In multivariate analyses, negative surgical margin ( p < 0.001), ypT0 stage ( p = 0.004), and ypN0 stage ( p = 0.020) were significantly favorable factors for PFS, and negative surgical margin ( p < 0.001) was the only significantly favorable factor for OS. Metastasis to the supraclavicular and/or celiac LNs was significant factor neither for PFS ( p = 0.311) nor OS ( p = 0.515). Supraclavicular and/or celiac LN metastasis did not compromise the clinical outcomes following NACRT and surgery.