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EFFECTS OF ESTROGEN AND COMBINED TREATMENT WITH ESTROGEN AND PROGESTERONE ON CENTRAL DOPAMINE, NORADRENALINE AND ADRENALINE NERVE TERMINAL SYSTEMS OF THE OVARIECTOMIZED RAT. RELATIONSHIP OF CHANGES IN AMINE TURNOVER TO CHANGES IN LH AND PROLACTIN SECRETION AND IN SEXUAL BEHAVIOUR

1981; Elsevier BV; Linguagem: Inglês

10.1016/b978-0-08-026864-4.50013-x

Kjell Fuxé, K. Andersson, Charles A. Blake, P. Eneroth, Jan-Ακε Gustafsson, L.F. Agnati,

Regulation of Appetite and Obesity

ABSTRACT The present experiments on hypophysectomized and castrated male rats and on ovariectomized female rats give evidence that: 1. Estradiol-17β by direct action on the brain possibly mediated via steroid target cells within the preoptic and hypothalamic area can markedly reduce DA turnover in mesostriatal and mesolimbic DA systems. Estrogen may in this way regulate motor functions and mental activities such as mood. 2. Estradiol-17β produces its central inhibitory feedback action on LHRH secretion, at least in part, via direct action on the hypothalamus leading to an activation of the lateral tuberoinfundibular dopamine pathway which in turn via an axo-axonic influence inhibits the secretion of LHRH from the median eminence. 3. Estradiol-17β may, at least in part, influence food intake via increasing NA turnover within the paraventricular hypothalamic nucleus and the anterior periventricular hypothalamic region. 4. Estradiol-17β may, at least in part, influence emotional behaviours via reducing the NA turnover within the amygdaloid-entorhinal area. 5. Estradiol-17β (48 h, 10 μg/kg) can selectively reduce adrenaline turnover within the posterior hypothalamus indicating that also adrenergic mechanisms in brain can be sensitive, directly or indirectly, to the action of the estradiol-17β. It is suggested that following estradiol-17β treatment with or without progesterone the discrete changes in DA, NA and adrenaline turnover discovered can be produced via actions not only on estrogen target cells within the amygdaloid cortex, the preoptic area and the hypothalamus, but also via direct actions of some of the DA and NA cell bodies themselves, since they have been shown to accumulate estrogen (see Stumpf, 1979 ).