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Cetartiodactyls evolved lacking the apoC-I gene

2016; Elsevier BV; Volume: 5; Linguagem: Inglês

10.1016/j.genrep.2016.09.007

2452-0144

Don L. Puppione,

Metabolomics and Mass Spectrometry Studies

In a previous study, cattle were reported to be lacking the apoC-I gene. This was concluded after detailed mass spectrometry analyses of the apolipoproteins associated with bovine HDL and an examination of the apoE - C-II cluster on chromosome 18. To see if this were also true for other cetartiodactyls, the genomes of pig, two cetaceans and a dromedary were search for evidence of the apoC-I gene. Although the apoE and C-IV genes, the genes that flank the apoC-I gene in the apoE - apoC-II cluster were located, there was no evidence of an apoC-I gene in these mammals. However, the sequences similar to those present in the two enhancers that flank the apoC-I gene on human chromosome 19 were found. Cetartiodactyls diverged into the separate subgroups of Cetacea, Hippopotamidae, Ruminantia, Suina and Tylopoda during the geological epoch Eocene. The absence of the gene in members of these diverse suborders would indicate that the gene had been deleted from a common ancestor 35 to 65 million years ago.