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Serum Chloride Analysis, Bromide Detection, and the Diagnosis of Bromism

1976; Oxford University Press; Volume: 65; Issue: 1 Linguagem: Inglês

10.1093/ajcp/65.1.49

1943-7722

Robert E. Wenk, Jack A. Lustgarten, NicholasD. Pappas, Robert I. Levy, R. C. Jackson,

Renal function and acid-base balance

Wenk, Robert E., Lustgarten, Jack A., Pappas, N. John, Levy, Robert I., and Jackson, Roger: Serum chloride analysis, bromide detection, and the diagnosis of bromism. Current methods for determining serum chloride concentration vary in specificity. Laboratory detection of bromide in serum is usually dependent on spuriously high chloride values. In the absence of historical information, the chemical identification of bromide in serum may be the only diagnostic sign of bromism. Bromide may be found in as many as 1% of sera obtained from inpatients of a general hospital. Ion-selective electrodes and some thiocyanate methods for chloride analysis can be highly sensitive to bromide (interference). Chloride electrodes are also sensitive to iodide.