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Amlodipine-induced gingival overgrowth in a child after liver transplant

2016; UNIVERSIDADE DE SÃO PAULO; Volume: 6; Issue: 3 Linguagem: Inglês

10.4322/acr.2016.041

2236-1960

André Guollo, ANA PAULA MOLINA VIVAS, Rodrigo Nascimento Lopes, Gilda Porta, Fábio Abreu Alves,

Pharmacological Effects and Toxicity Studies

Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver transplant due to biliary atresia 3 years ago, immunosuppressive therapy, and hypertension, which is why she was started on a daily intake of amlodipine. The intraoral examination showed generalized GO, and the treatment consisted of a gingivectomy. Subsequently, amlodipine was replaced with captopril and oral hygiene instructions. There was no recurrence of GO after 28 months of follow-up. Although GO may be related to the chronic use of amlodipine, such an association is uncommon in pediatrics, and the treatment consists of the replacement of medication combined with a surgical approach and plaque control.