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Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation

2016; Wiley; Volume: 5; Issue: 21 Linguagem: Inglês

10.1002/adhm.201600497

2192-2659

Lei Cai, Ruby E. Dewi, Andrew B. Goldstone, Jeffrey Е. Cohen, Amanda N. Steele, Y. Joseph Woo, Sarah C. Heilshorn,

Electrospun Nanofibers in Biomedical Applications

A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200–400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.