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Enantioselective lipase catalyzed esterification in organic medium for preparation of optically active secondary alcohols

1989; Springer Science+Business Media; Volume: 189; Issue: 2 Linguagem: Inglês

10.1007/bf01332949

0044-3026

Doris Gerlach, Detlef Lutz, Boris Mey, Peter Schreier,

Electrochemical sensors and biosensors

The homologous series of aliphatic 2-alkanols (2-pentanol to 2-decanol) and three phenylalkanols (1-phenylethanol; 1-phenyl-l-propanol; 1-phenyl-2-propanol) were prepared in high chemical (40–80% of theoretical value) and optical yields (78–100% enantiomeric excess) by enantio-selective esterification in organic medium using catalysis with porcine pancreas lipase. The dependence of the enantio selectivity of catalysis on temperature, chain length of substrates and enzyme immobilization was studied.