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Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms

2016; IOS Press; Volume: 55; Issue: 2 Linguagem: Inglês

10.3233/jad-160164

1875-8908

Luís Felipe José Ravic de Miranda, Karina Braga Gomes, Pedro Augusto Lopes Tito, Josianne Nicácio Silveira, Gérson Antônio Pianetti, Ricardo Martins Duarte Byrro, Patrícia Regina Henrique Peles, Fernando H. Pereira, Thiago Rezende dos Santos, Arthur G. Assini, Valéria V. Ribeiro, Edgar Nunes de Moraes, Paulo Caramelli,

Schizophrenia research and treatment

The clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer's disease (AD) and AD with cerebrovascular di sease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma concentrations were measured after 3, 6, and 12 months. Good responders scored ≥–1 on the Mini-Mental State Examination at 12 months in comparison to the baseline score. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms.