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Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian population

2016; European Respiratory Society; Volume: 48; Issue: 6 Linguagem: Inglês

10.1183/13993003.00443-2016

1399-3003

Arnulf Langhammer, Ane Johannessen, Turid Lingaas Holmen, Hasse Melbye, Sanja Stanojevic, May Britt Lund, Morten Nissen Melsom, Per Bakke, Philip H. Quanjer,

Respiratory Support and Mechanisms

We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease. Spirometry data collected in 30 239 subjects (51.7% females) aged 12–90 years in three population-based studies were converted to z-scores. We studied healthy non-smokers comprising 2438 adults (57.4% females) aged 20–90 years and 8725 (47.7% female) adolescents aged 12–19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median± sd z-scores were respectively 0.02±1.03, 0.01±1.04 and −0.04±0.91 for forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC) and FEV 1 /FVC in males, and −0.01±1.02, 0.07±0.97 and −0.21±0.82 in females. The ECSC and Zapletal references significantly underestimated FEV 1 and FVC. Stricter criteria of obstruction (FEV 1 /FVC <GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV 1 /FVC <0.7 and >GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a four-fold higher risk for women. The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV 1 /FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV 1 /FVC <0.7.