A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
2016; American Association for the Advancement of Science; Volume: 354; Issue: 6308 Linguagem: Inglês
10.1126/science.aad6872
ISSN1095-9203
AutoresYingfei Wang, Ran An, George K. E. Umanah, Hyejin Park, Kalyani Nambiar, Stephen Eacker, BongWoo Kim, Lei Bao, Maged M. Harraz, Calvin Chang, Rong Chen, Jennifer E. Wang, Tae‐In Kam, Jun Seop Jeong, Zhi Xie, Stewart Neifert, Jiang Qian, Shaida A. Andrabi, Seth Blackshaw, Heng Zhu, Hongjun Song, Guo‐li Ming, Valina L. Dawson, Ted M. Dawson,
Tópico(s)Macrophage Migration Inhibitory Factor
ResumoDNA damage-activated nuclease identified Cells that experience stresses and accumulate excessive damage to DNA undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates to the nucleus and activates one or more nucleases to cleave DNA. Wang et al. found that macrophage migration inhibitory factor (MIF) is an AIF-associated endonuclease that contributes to PARP-1-induced DNA fragmentation (see the Perspective by Jonas). In mouse neurons in culture, loss of MIF protected neurons from cell death caused by excessive stimulation. Targeting MIF could thus provide a therapeutic strategy against diseases in which PARP-1 activation is excessive. Science , this issue p. 82 ; see also p. 36
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