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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

2016; Springer Science+Business Media; Volume: 11; Issue: 5 Linguagem: Inglês

10.1007/s11682-016-9629-z

1931-7565

Tulio Guadalupe, Samuel R. Mathias, Theo G. M. vanErp, Christopher D. Whelan, Marcel P. Zwiers, Yoshinari Abe, Lucija Abramovic, Ingrid Agartz, Ole A. Andreassen, Alejandro Arias Väsquez, Benjamin S. Aribisala, Nicola J. Armstrong, Volker Arolt, Éric Artiges, Rosa Ayesa‐Arriola, Vatche G. Baboyan, Tobias Banaschewski, Gareth J. Barker, Mark E. Bastin, Bernhard T. Baune, John Blangero, Arun L.W. Bokde, Premika S.W. Boedhoe, Anushree Bose, Silvia Brem, Henry Brodaty, Uli Bromberg, Samantha J. Brooks, Christian Büchel, Jan K. Buitelaar, Vince D. Calhoun, Dara M. Cannon, Anna Cattrell, Yuqi Cheng, Patricia Conrod, Annette Conzelmann, Aiden Corvin, Benedicto Crespo‐Facorro, Fabrice Crivello, Udo Dannlowski, Greig I. de Zubicaray, Sonja M. C. de Zwarte, Ian J. Deary, Sylvane Desrivières, Nhat Trung Doan, Gary Donohoe, Erlend S. Dørum, Stefan Ehrlich, Thomas Espeseth, Guillén Fernández, Herta Flor, Jean-Paul Fouche, Vincent Frouin, Masaki Fukunaga, Jürgen Gallinat, Hugh Garavan, Michael Gill, Andrea González Suárez, Penny Gowland, Hans J. Grabe, Dominik Grotegerd, Oliver Gruber, Saskia P. Hagenaars, Ryota Hashimoto, Tobias U. Hauser, Andreas Heinz, Derrek P. Hibar, Pieter J. Hoekstra, Martine Hoogman, Fleur M. Howells, Hao Hu, Hilleke E. Hulshoff Pol, Chaim Huyser, Bernd Ittermann, Neda Jahanshad, Erik G. Jönsson, Sarah Jurk, René S. Kahn, Sinéad Kelly, Bernd Kraemer, Harald Kugel, Jun Soo Kwon, Hervé Lemaître, Klaus‐Peter Lesch, Christine Löchner, Michelle Luciano, André F. Marquand, Nicholas G. Martin, Ignacio Martínez‐Zalacaín, Jean‐Luc Martinot, David Mataix‐Cols, Karen A. Mather, Colm McDonald, Katie L. McMahon, Sarah E. Medland, José M. Menchón, Derek W. Morris, Omar Mothersill, Susana Muñoz Maniega, Benson Mwangi, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswaamy, Frauke Nees, Jan Egil Nordvik, A. Marten H. Onnink, Nils Opel, Roel A. Ophoff, Marie‐Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Paul Pauli, Tomáš Paus, Luise Poustka, Janardhan Y. C. Reddy, Miguel E. Rentería, Roberto Roiz‐Santiáñez, Annerine Roos, Natalie A. Royle, Perminder S. Sachdev, Pascual Sánchez‐Juan, Lianne Schmaal, Günter Schumann, Elena Shumskaya, Michael N. Smolka, Jair C. Soares, Carles Soriano‐Mas, Dan J. Stein, Lachlan T. Strike, Roberto Toro, Jessica A. Turner, Nathalie Tzourio‐Mazoyer, Anne Uhlmann, María Valdés Hernández, Odile A. van den Heuvel, Dennis van der Meer, Neeltje E. M. van Haren, Dick J. Veltman, Ganesan Venkatasubramanian, Nora C. Vetter, Daniella Vuletic, Susanne Walitza, Henrik Walter, Esther Walton, Zhen Wang, Joanna M. Wardlaw, Wei Wen, Lars T. Westlye, Robert Whelan, Katharina Wittfeld, Thomas Wolfers, Margaret J. Wright, Jian Xu, Xiufeng Xu, Je-Yeon Yun, JingJing Zhao, Barbara Franke, Paul M. Thompson, David C. Glahn, Bernard Mazoyer, Simon E. Fisher, Clyde Francks,

Spatial Neglect and Hemispheric Dysfunction

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.