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Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery

2016; IOP Publishing; Volume: 7; Issue: 4 Linguagem: Inglês

10.1088/2043-6262/7/4/045010

2043-6262

Xuan Nui Pham, Tan Phuoc Nguyen, Tuyet Nhung Pham, Thi Thuy Nga Tran, Thị Văn Thi Trần,

Advancements in Transdermal Drug Delivery

In this work anti-cancer drug curcumin-loaded superparamagnetic iron oxide (Fe3O4) nanoparticles was modified by chitosan (CS). The magnetic iron oxide nanoparticles were synthesized by using reverse micro-emulsion (water-in-oil) method. The magnetic nanoparticles without loaded drug and drug-loaded magnetic nanoparticles were characterized by XRD, FTIR, TG-DTA, SEM, TEM, and VSM techniques. These nanoparticles have almost spherical shape and their diameter varies from 8 nm to 17 nm. Measurement of VSM at room temperature showed that iron oxide nanoparticles have superparamagnetic properties. In vitro drug loading and release behavior of curcumin drug-loaded CS-Fe3O4 nanoparticles were studied by using UV-spectrophotometer. In addition, the cytotoxicity of the modified nanoparticles has shown anticancer activity against A549 cell with IC50 value of 73.03 μg/ml. Therefore, the modified magnetic nanoparticles can be used as drug delivery carriers on target in the treatment of cancer cells.