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Role of adenosine A2b receptor overexpression in tumor progression

2016; Elsevier BV; Volume: 166; Linguagem: Inglês

10.1016/j.lfs.2016.10.008

1879-0631

Cèsar Sepùlveda, Iván Palomo, Eduardo Fuentes,

Receptor Mechanisms and Signaling

The adenosine A2b receptor is a G-protein coupled receptor. Its activation occurs with high extracellular adenosine concentration, for example in inflammation or hypoxia. These conditions are generated in the tumor environment. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. Thus A2b participates in different events, such as angiogenesis and metastasis, besides exerting immunomodulatory effects that protect tumor cells. Therefore, adenosine A2b receptor appears as an interesting therapeutic target for cancer treatment.