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A frameshift deletion in the sarcomere gene MYL4 causes early-onset familial atrial fibrillation

2016; Oxford University Press; Volume: 38; Issue: 1 Linguagem: Inglês

10.1093/eurheartj/ehw379

1522-9645

Daníel F. Guðbjartsson, Hilma Hólm, Patrick Sulem, Gísli Másson, Ásmundur Oddsson, Ólafur Þ. Magnússon, Jona Saemundsdottir, Hafdís T. Helgadóttir, Hannes Helgason, Hrefna Johannsdottir, Sólveig Grétarsdóttir, Sigurjón A. Guðjónsson, Inger Njølstad, Maja‐Lisa Løchen, Larry Baum, Ronald C.W., Gunnlaugur Sigfússon, Augustine Kong, Guðmundur Þorgeirsson, Jon T. Sverrisson, Unnur Þorsteinsdóttir, Kári Stéfansson, Davíð O. Arnar,

Cardiomyopathy and Myosin Studies

AimsAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF.