Portal de Periódicos da CAPES

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

2016; Oxford University Press; Volume: 45; Issue: D1 Linguagem: Inglês

10.1093/nar/gkw960

1362-4962

Kai Blin, Marnix H. Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber,

Plant biochemistry and biosynthesis

Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.