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The effects of nifedipine on respiratory mechanics investigated by theend-inflation occlusion method in the rat

2016; Taylor & Francis; Volume: 32; Issue: 1 Linguagem: Inglês

10.1080/14756366.2016.1225045

1475-6374

Alessandro Rubini, Vincenzo Catena, Daniele Del Monte, Gerardo Bosco,

Pharmacological Receptor Mechanisms and Effects

Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle.To investigate possible effects of nifedipine on respiratory mechanics in the rat.Respiratory system mechanical parameters were measured by the end-inflation occlusion method in the rat in vivo before and after the intraperitoneal administration of nifedipine.We found that nifedipine affects respiratory mechanics, inducing a reduction of airway resistance and of respiratory system elastance, probably because of a relaxing action on airway and parenchimal smooth muscle cells.Should these results be further confirmed by human investigations, a possible role of nifedipine in pharmacological respiratory system's diseases treatment may be suggested.