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ANTIULCER ACTIVITY OF Musa paradisiaca (BANANA) TEPAL AND SKIN EXTRACTS IN ULCER INDUCED ALBINO MICE

2016; Volume: 20; Issue: 5 Linguagem: Inglês

10.17576/mjas-2016-2005-27

1394-2506

Bashir Ahmad,

Biochemical Analysis and Sensing Techniques

The current use of ulcer drugs is limited due to its side effects and potentiality of relapse.This study aimed to ascertain the antiulcer potentials of the tepal and skin extracts of banana Musa paradisiaca.The parts were processed and extracted using methanol by maceration.Phytochemicals content of both parts were screened.Twenty-five albino mice were used in in vivo analysis.The mice were treated with 100 mg/kg of tepal and skin extract as well as cimetidine for seven days followed by administration of indomethacin.The animals were sacrificed, and the removed stomachs were prepared for the evaluation of ulcer index and gastric wall mucus.pH and volume were measured from the gastric juice.The results revealed that banana's tepal and skin extracts contain phytochemicals like phenols, flavonoids and etc.The tepal and skin extracts prevented the IND+PYL induced ulcer by 68.80 ± 20.53% and 43.22 ± 14.82% respectively.Significant rise (p 0.05).Findings from this study shows that banana's tepal and skin were able to prevent IND+PYL induced ulcer by strengthening the gastric mucosa and decreasing the gastric juice acidity.