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Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations

2016; Elsevier BV; Volume: 22; Issue: 2 Linguagem: Inglês

10.1016/j.drudis.2016.10.011

1878-5832

Gillian R. Langley, Ian M. Adcock, François Busquet, Kevin M. Crofton, Elena Csernok, Christoph Giese, Tuula Heinonen, Kathrin Herrmann, Martin Hofmann‐Apitius, Brigitte Landesmann, Lindsay J. Marshall, Emily McIvor, Alysson R. Muotri, Noor Fatima, Katrin Schütte, Troy Seidle, Anja van de Stolpe, Hilde Van Esch, Catherine Willett, Grzegorz Woszczek,

Computational Drug Discovery Methods

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.