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BIBTEX RIS

Biopharmaceuticals from microorganisms: from production to purification

2016; Springer Nature; Volume: 47; Linguagem: Inglês

10.1016/j.bjm.2016.10.007

1678-4405

Ângela Faustino Jozala, Danilo Costa Geraldes, Louise Lacalendola Tundisi, Valker de Araújo Feitosa, Carlos Alexandre Breyer, Samuel Leite Cardoso, Priscila Gava Mazzola, Laura de Oliveira Nascimento, Carlota de Oliveira Rangel‐Yagui, Pérola Oliveira Magalhães, Marcos Antônio de Oliveira, Adalberto Pessoa,

Protein purification and stability

The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.