Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)
2015; Wiley; Volume: 13; Issue: 7 Linguagem: Inglês
10.2903/j.efsa.2015.4150
ISSN1831-4732
Tópico(s)Iron Metabolism and Disorders
ResumoEFSA JournalVolume 13, Issue 7 4150 OpinionOpen Access Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12) EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)Search for more papers by this author EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)Search for more papers by this author First published: 09 July 2015 https://doi.org/10.2903/j.efsa.2015.4150Citations: 35 Panel members: Carlo Agostoni, Roberto Berni Canani, Susan Fairweather-Tait, Marina Heinonen, Hannu Korhonen, Sébastien La Vieille, Rosangela Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé, Dominique Turck and Hans Verhagen. Correspondence: nda@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group on Dietary Reference Values for vitamins: Christel Lamberg-Allardt, Monika Neuhäuser-Berthold, Grażyna Nowicka, Kristina Pentieva, Hildegard Przyrembel, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé and Dominique Turck for the preparatory work on this scientific opinion and EFSA staff: Anja Brönstrup, Agnès de Sesmaisons-Lecarré, Sofia Ioannidou and Liisa Valsta for the support provided to this scientific opinion. Adoption date: 11 June 2015 Published date: 9 July 2015 Question number: EFSA-Q-2011-01227 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12). The Panel considers that the approach based on a combination of biomarkers of cobalamin status, i.e. serum cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA) and plasma total homocysteine (tHcy), is the most suitable approach to derive DRVs for cobalamin. The Panel notes the uncertainties with respect to cut-off values for cobalamin insufficiency of these indicators and that an Average Requirement (AR) cannot be determined from the limited data available. There is consistent evidence in adults that a cobalamin intake of 4 μg/day and greater is associated with serum concentrations of holoTC and cobalamin within the reference ranges derived from healthy subjects, together with MMA and tHcy concentrations below the cut-off values for adults, which indicates an adequate cobalamin status. Therefore, the Panel sets an Adequate Intake (AI) for cobalamin at 4 μg/day for adults based on data on different biomarkers of cobalamin status and in consideration of observed mean intakes, which range between 4.2 and 8.6 μg/day in adults in several EU countries. AIs for infants and children are calculated by extrapolation from the AI for adults using allometric scaling and applying a growth factor. Estimated AIs range from 1.5 μg/day in infants aged 7–11 months to 4 μg/day in children aged 15–17 years. For pregnancy and lactation, additional cobalamin intakes related to the accumulation of cobalamin in fetal tissues and transfer of cobalamin into breast milk are considered and AIs of 4.5 and 5 μg/day, respectively, are proposed. References Abdulla M, Andersson I, Asp NG, Berthelsen K, Birkhed D, Dencker I, Johansson CG, Jagerstad M, Kolar K, Nair BM, Nilsson-Ehle P, Norden A, Rassner S, Akesson B and Ockerman PA, 1981. Nutrient intake and health status of vegans. 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