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Antioxidant and Anti-Proliferative Activity of Calamintha officinalis Extract on Breast Cancer Cell Line MCF-7

2015; Asian Network for Scientific Information; Volume: 15; Issue: 4 Linguagem: Inglês

10.3923/jbs.2015.194.198

1812-5719

Fatemeh Shams Moattar, Reyhaneh Sariri, Masoud Giahi, Prichehr Yaghmaee, Hosein Ghafoori, Leila Jamalzadeh,

Natural Antidiabetic Agents Studies

The aim of this study was evaluation of antioxidant and anti-proliferative activities of the Calamintha officinalis Moench (COM).Calamintha officinalis is a genus of aromatic herbs, which is native in north parts of Iran.Some of its pharmaceutical profits are already known, however, a scientific evidence seems necessary before any proposal for its pharmaceutical arrangements.Total antioxidant activity of the plant extract was assayed by spectrophotometric methods.Folin-ciocalteu reagent assay was used to evaluate the phenolic contents of extract.A zymogram assay of peroxidase (POX) was performed to observe its activity.Antiproliferative activity of the plant extract was examined on human breast cancer cell line (MCF-7) using [3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) method.The results showed a considerable antioxidant activity and a high reducing power.On the other hand, a reasonable antiproliferative role played by the extract, the POX in this plant is composed of two isozymes.The results indicated that COM can be regarded as a suitable candidate for designing anticancer pharmaceutical preparations.