Epinephrine Treatment of Anaphylaxis
2009; Lippincott Williams & Wilkins; Volume: 2; Issue: 1 Linguagem: Inglês
10.1161/circinterventions.108.820266
ISSN1941-7632
AutoresColette E. Jackson, Jonathan R. Dalzell, Kerry J. Hogg,
Tópico(s)Cardiac Arrhythmias and Treatments
ResumoHomeCirculation: Cardiovascular InterventionsVol. 2, No. 1Epinephrine Treatment of Anaphylaxis Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree AccessResearch ArticlePDF/EPUBEpinephrine Treatment of AnaphylaxisAn Extraordinary Case of Very Late Acute Stent Thrombosis Colette E. Jackson, Jonathan R. Dalzell and Kerry J. Hogg Colette E. JacksonColette E. Jackson From the British Heart Foundation Cardiovascular Research Centre (C.E.J., J.R.D.), University of Glasgow, Glasgow, United Kingdom; and West of Scotland Regional Heart and Lung Centre (K.J.H.), Golden Jubilee National Hospital, Clydebank, Glasgow, United Kingdom. , Jonathan R. DalzellJonathan R. Dalzell From the British Heart Foundation Cardiovascular Research Centre (C.E.J., J.R.D.), University of Glasgow, Glasgow, United Kingdom; and West of Scotland Regional Heart and Lung Centre (K.J.H.), Golden Jubilee National Hospital, Clydebank, Glasgow, United Kingdom. and Kerry J. HoggKerry J. Hogg From the British Heart Foundation Cardiovascular Research Centre (C.E.J., J.R.D.), University of Glasgow, Glasgow, United Kingdom; and West of Scotland Regional Heart and Lung Centre (K.J.H.), Golden Jubilee National Hospital, Clydebank, Glasgow, United Kingdom. Originally published1 Feb 2009https://doi.org/10.1161/CIRCINTERVENTIONS.108.820266Circulation: Cardiovascular Interventions. 2009;2:79–81A 78-year-old man experienced marked angioedema of his face and tongue following ingestion of chocolate-coated peanuts. Paramedics administered 0.5 mg of intramuscular epinephrine within half an hour of symptom onset with rapid relief of symptoms and subsidence of the swelling. On route to the local Emergency Department the patient suddenly became pale, nauseous, and began sweating profusely. There was no chest pain. Blood pressure was 182/105 and heart rate 107 beats per minute. An ECG revealed sinus tachycardia and marked anterior ST elevation (Figure 1), and he was urgently transferred to the regional interventional cardiology center. Aspirin 300 mg and clopidogrel 600 mg were administered before transfer. He had a significant history of coronary artery disease and 4 years previously had undergone percutaneous coronary intervention to the proximal left anterior descending (LAD) and proximal circumflex arteries with bare-metal stents. Three months following this he developed in-stent restenosis in the LAD stent that was treated by further percutaneous coronary intervention with 2 overlapping drug-eluting stents. He experienced infrequent exertional angina over the next 4 years and at the time of this presentation was taking aspirin 75 mg as a sole antiplatelet. There was no history of diabetes, noncompliance with aspirin therapy, or any other medical history suggestive of a hypercoagulable state. Download figureDownload PowerPointFigure 1. ECG on presentation showing acute anterior ST elevation myocardial infarction.On arrival in the catherization laboratory 5000 IU heparin was administered intravenously. Coronary angiography showed a large dominant right system supplying collaterals to the circumflex artery. The LAD was occluded midway through the drug-eluting stents (Figure 2 and Supplemental Figure A). The circumflex was also blocked within the bare metal stent but was an unlikely culprit lesion given the anterior ECG changes, and the collateralization provided by the right coronary artery (RCA) to the level of the circumflex stent. A guide wire was passed to the distal LAD, the artery reopened and obvious focal clot visualized. Thrombus extraction, via an Export aspiration catheter, followed by balloon dilatation to high pressure restored TIMI 3 flow (Figure 3 and Supplemental Figure B) with complete resolution of the ECG changes (Figure 4). Surprisingly, there was no evidence of any significant in-stent restenosis and therefore no stent was deployed. Post-percutaneous coronary intervention medical care included glycoprotein IIb/IIIa inhibitor infusion and a recommendation for life-long dual antiplatelet therapy. The patient made an uncomplicated recovery and was provided with an epinephrine pen predischarge. Download figureDownload PowerPointFigure 2. Right anterior oblique view at emergency coronary angiography showing occlusion of the LAD and circumflex stents.Download figureDownload PowerPointFigure 3. Restoration of flow within the LAD following thrombus extraction.Download figureDownload PowerPointFigure 4. ECG post-LAD recanalization revealing resolution of the anterior ST elevation seen in Figure 1.In humans, exogenous epinephrine administration has been shown to promote platelet aggregation1 by increasing platelet production of thromboxane B2,2 heightening the sensitivity of platelets to ADP2 and promoting the thrombin induced binding of platelets to fibrinogen.3 Interestingly, platelets from angina patients are more sensitive to increased endogenous serum catecholamine levels, and thus more prone to aggregation compared with normal controls.4Late and very late-stent thromboses are recognized complications of percutaneous coronary intervention occurring more than 30 days and 1 year, respectively, postprocedure. Discontinuation of antiplatelet therapy is the commonest factor associated with these rare complications. Factors known to be associated with stent thrombosis include, among others, left ventricular systolic dysfunction and index stenting in the setting of acute myocardial infarction, conditions that are both associated with increased circulating catecholamine levels.We believe that this is the first reported case of acute drug-eluting stents thrombosis induced by exogenous epinephrine administration. The lack of in-stent restenosis in the culprit drug-eluting stents makes this case all the more noteworthy as epinephrine induced occlusion of a significant in-stent restenosis would have been a more expected scenario. This case identifies the need for further work to ascertain any potential role of long-term dual antiplatelet therapy in patients with coronary stents in situ who are likely to require epinephrine therapy for allergic angioedema. Moreover, we are reminded that any stimulus increasing catecholamine levels, be it exogenous or endogenous (eg, trauma or surgery), can predispose patients to thrombosis, which may be catastrophic for those with coronary stents in situ.Statement of ResponsibilityThe authors had full access to and take full responsibility for the integrity of the data. All authors have read and agree to the manuscript as written.The online Data Supplement is available at http://circinterventions.ahajournals.org/cgi/content/full/2/1/79/DC1.DisclosuresNone.FootnotesCorrespondence to Dr Colette E. Jackson, BHF Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK. E-mail [email protected] References 1 Larsson PT, Hjemdahl P, Olsson G, Egberg N, Hornstra G. Altered platelet function during mental stress and adrenaline infusion in humans: evidence for an increased aggregability in vivo as measured by filtragometry. Clin Sci (Lond). 1989; 76: 369–376.CrossrefMedlineGoogle Scholar2 Laustiola K, Kaukinen S, Seppälä E, Jokela T, Vapaatalo H. Adrenaline infusion evokes increased thromboxane B2 production by platelets in healthy men: the effect of beta-adrenoceptor blockade. Eur J Clin Invest. 1986; 16: 473–479.CrossrefMedlineGoogle Scholar3 Wallén NH, Goodall AH, Li N, Hjemdahl P. Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation. Clin Sci (Lond). 1999; 97: 27–35.CrossrefMedlineGoogle Scholar4 Wallén NH, Held C, Rehnqvist N, Hjemdahl P. Effects of mental and physical stress on platelet function in patients with stable angina pectoris and healthy controls. 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Kasim S, AbuBakar R and McFadden E (2012) Anaphylaxis from Wasp Stings Inducing Coronary Thrombus, Case Reports in Cardiology, 10.1155/2012/701753, 2012, (1-3), . Schachter M (2011) Drugs that affect autonomic functions or the extrapyramidal system A worldwide yearly survey of new data in adverse drug reactions, 10.1016/B978-0-444-53741-6.00013-1, (313-331), . February 2009Vol 2, Issue 1 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCINTERVENTIONS.108.820266PMID: 20031696 Originally publishedFebruary 1, 2009 Keywordsstentsthrombosismyocardial infarctionanaphylaxisepinephrinePDF download Advertisement SubjectsCoronary CirculationMyocardial InfarctionPlateletsStentThrombosis
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