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Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma

2016; Impact Journals LLC; Volume: 7; Issue: 48 Linguagem: Inglês

10.18632/oncotarget.13033

1949-2553

Qianqian Wang, Xiangyuan Yu, Qiang Li, Linyuan Qin, Shengkui Tan, Xiaoyun Zeng, Xiaoqiang Qiu, Bo Tang, Junfei Jin, Weijia Liao, Moqin Qiu, Lijun Tan, Gaofeng He, Xiaomei Li, Songqing He, Hongping Yu,

Cancer-related molecular mechanisms research

// Qianqian Wang 2, * , Xiangyuan Yu 2, * , Qiang Li 2 , Linyuan Qin 2 , Shengkui Tan 2 , Xiaoyun Zeng 1 , Xiaoqiang Qiu 1 , Bo Tang 3 , Junfei Jin 3 , Weijia Liao 3 , Moqin Qiu 3 , Lijun Tan 3 , Gaofeng He 3 , Xiaomei Li 2 , Songqing He 3, 4 , Hongping Yu 1, 2 1 Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning 530021, China 2 Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China 3 Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China 4 Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin 541001, China * These authors contributed equally to this work Correspondence to: Hongping Yu, email: yhp268@163.com Songqing He, email: dr_hesongqing@163.com Keywords: hepatocellular carcinoma, miR-199a, MET, single nucleotide polymorphism, risk Received: April 22, 2016 Accepted: October 21, 2016 Published: November 02, 2016 ABSTRACT MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings.