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CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy

2016; Lippincott Williams & Wilkins; Volume: 87; Issue: 23 Linguagem: Inglês

10.1212/wnl.0000000000003401

1526-632X

Béatrice Pignolet, Nicholas Schwab, Tilman Schneider‐Hohendorf, Florence Bucciarelli, Damien Biotti, Delphine Averseng-Peaureaux, Olivier Outteryck, Jean-Claude Ongagna, de Sèze, Bruno Brochet, Jean‐Christophe Ouallet, Marc Debouverie, Sophie Pittion, Gilles Defer, Nathalie Derache, Patrick Hautecœur, Ayman Tourbah, Pierre Labauge, Giovanni Castelnovo, Pierre Clavelou, Éric Berger, Jean Pelletier, Audrey Rico, Hélène Zéphir, David Laplaud, Sandrine Wiertlewski, William Camu, Éric Thouvenot, Olivier Casez, Thibault Moreau, Agnès Fromont, Sandra Vukusic, Caroline Papeix, Patrick Vermersch, Manuel Comabella, Christine Lebrun‐Frénay, Heinz Wiendl, David Brassat, David Brassat, Béatrice Pignolet, Florence Bucciarelli, Nicholas Schwab, Tilman Schneider‐Hohendorf, Heinz Wiendel, Manuel Comabella, Nicolás Fissolo, María Martínez, Alexia di-Paolo, Florence Umuhoza, Lise Scandella, Sarah Exbrayat, David Brassat, Olivier Outteryck, Jean-Claude Ongagna, de Sèze, Bruno Brochet, Jean‐Christophe Ouallet, Marc Debouverie, Sophie Pittion, Gilles Defer, Nathalie Derache, Patrick Hautecœur, Ayman Tourbah, Prof Pierre Labauge, Giovanni Castelnovo, Pierre Clavelou, Éric Berger, Jean Pelletier, Audrey Rico, Hélène Zéphir, David Laplaud, Sandrine Wiertlewski, Philippe Cabre, William Camu, Éric Thouvenot, Olivier Casez, MD . Thibault Moreau, Agnès Fromont, Sandra Vukusic, Caroline Papeix, Catherine Lubetzki, Patrick Vermersch, Christine Lebrun‐Frénay, Mikaël Cohen, MD Lucien Rumbach, Olivier Heinzlef, Prof Jérôme de Sèze, Sophie Pittion, Hélène Zéphir, Olivier Anne, Bertrand Audoin, Caroline Bensa, Éric Berger, David Brassat, Prof Bruno Brochet, Bertrand Bourre, Philippe Cabre, Jean‐Philippe Camdessanché, Olivier Casez, Giovanni Castelnovo, Pierre Clavelou, Nicolas Collongues, Marc Coustans, Alain Créange, MD PhD Marc Debouverie, Nathalie Derache, Prof Gilles Defer, Dominique Dive, MD Gilles Edan, Agnès Fromont, Olivier Gout, Riadh Gouider, Jérôme Grimaud, Patrick Hautecœur, Arnaud Kiatkoswki, Pierre Labauge, David Laplaud, Christine Lebrun‐Frénay, E. Lepage, Romain Marignier, Thibault Moreau, Jean‐Christophe Ouallet, Caroline Papeix, Jean Pelletier, L. Rumbach, Myriam Schluep, Pierrette Seeldrayers, Ilham Slassi Sennou, Bruno Stankoff, Frédéric Taithe, Ayman Tourbah, Éric Thouvenot, Patrick Vermersch, Sandra Vukusic, Sandrine Wiertlewski,

RNA regulation and disease

Flashes of light or phosphenes are the sensation of light without light actually entering the eye. This phenomenon can be evoked by stimulation of the retina or the visual cortex of the brain and can appear unilaterally or bilaterally. From an ophthalmologic perspective, phosphenes can arise from photoreceptor induction by mechanical,1,2 inflammatory,3 or vascular4 stimuli. Therefore, it is necessary to determine the origin of phosphenes for further management. We encountered a patient who reported having phosphenes while moving his eyes laterally. We performed various ophthalmologic imaging studies to identify the origin of these phosphenes. Acknowledgment: The authors thank Florence Umuhoza, Lise Scandella, and Sarah Exbrayat for technical assistance and the patients for participation in the study.