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From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)

2016; Wiley; Volume: 56; Issue: 2 Linguagem: Inglês

10.1002/anie.201510610

1521-3773

Julia Mantaj, Paul J. Jackson, Khondaker Miraz Rahman, David E. Thurston,

Cancer Treatment and Pharmacology

The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a covalent aminal bond between their C11-position and the C2-NH