Portal de Periódicos da CAPES

Evaluation of Anti-inflammatory and Analgesic Activities of Cymbopogon citratus In vivo-Polyphenols Contribution

2015; Volume: 9; Issue: 1 Linguagem: Inglês

10.3923/rjmp.2015.1.13

2151-7924

Gustavo Costa, Rita Garcia, João P. S. Ferreira, Telmo N. Santos, Fábio Branco, Margarida Caramona, Rui A. Carvalho, Augusto M. Dinis, Maria Teresa Batista, Margarida Castel‐Branco, Isabel Vitória Figueiredo,

Natural Antidiabetic Agents Studies

Cymbopogon citratus is one of the most common herbs used in folk medicine due to its anti-inflammatory and antioxidant properties.Taking into account these properties showed on in vitro assays, the aim of this study was to evaluate the anti-inflammatory and analgesic activities of C. citratus leaves infusion (CcE) and its flavonoid-rich (CcF) and tannin-rich (CcT) fractions.The evaluation of the anti-inflammatory activity was performed in the carrageenan-induced rat paw oedema model.Both central and peripheral analgesic activities were evaluated in mice through the hot plate test and the acetic acid-induced writhing test, respectively.In the acute inflammation model, the statistically significant results obtained in percentage of oedema inhibition were 70.80 and 82.30% for CcE (34.12 and 68.24 mg kgG , respectively), 59.00% for CcF 1 (7.42 mg kgG ), 61.00% for CcT (5.96 mg kgG ) and 84.00% for positive control group 1 1(10 mg kgG ).For the peripheral pain evaluation, statistically significant results showed a pain 1 reduction of 57.00% for CcE (136.48 mg kgG ), 54.60% for CcF (14.8 mg kgG ), 52.20% for CcT 1 1 (11.92 mg kgG ) and 83.00% for positive control group.This study demonstrates that C. citratus 1 infusion compounds are able to reduce inflammation and peripheral pain in vivo, with polyphenols showing a significant contribution for these activities.