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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Association of BDNF Val66MET Polymorphism With Parkinson’s Disease and Depression and Anxiety Symptoms

2016; American Psychiatric Association Publishing; Volume: 29; Issue: 2 Linguagem: Inglês

10.1176/appi.neuropsych.16040062

ISSN

1545-7222

Autores

Fernanda C. Cagni, Clarissa Loureiro das Chagas Campêlo, Daniel Gomes Coimbra, Mayara Rodrigues Barbosa, Luiz Gonzaga Oliveira Júnior, Antônio Braz Silva Neto, Alessandra Mussi Ribeiro, Clécio de Oliveira Godeiro Júnior, Tiago Gomes de Andrade, Regina H. Silva,

Tópico(s)

Autism Spectrum Disorder Research

Resumo

An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.

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