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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury

2016; Elsevier BV; Volume: 38; Linguagem: Inglês

10.1016/j.jcrc.2016.11.010

ISSN

1557-8615

Autores

Eva Tejerina, Paolo Pelosi, Alfonso Muriel, Óscar Peñuelas, Yuda Sutherasan, Fernando Frutos‐Vivar, Nicolás Nín, Andrew R. Davies, Fernando Ríos, Damian A. Violi, Konstantinos Raymondos, Javier Hurtado, Marco González, Bin Du, Pravin Amin, Salvatore Maurizio Maggiore, Arnaud W. Thille, Marco Antonio Soares, Manuel Jibaja, Asisclo Villagómez, Michaël Kuiper, Younsuck Koh, Rui P. Moreno, Amine Ali Zeggwagh, Dimitrios Matamis, Antonio Anzueto, Niall D. Ferguson, Martin Dres,

Tópico(s)

Intensive Care Unit Cognitive Disorders

Resumo

In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. We performed a secondary analysis of a prospective, observational study on mechanical ventilation. We included 986 patients mechanically ventilated due to an acute brain injury (hemorrhagic stroke, ischemic stroke or brain trauma). Incidence of ARDS in this cohort was 3%. Multivariate analysis suggested that driving pressure could be associated with the development of ARDS (odds ratio for unit increment of driving pressure 1.12; confidence interval for 95%: 1.01 to 1.23) whereas we did not observe association for tidal volume (in ml per kg of predicted body weight) or level of PEEP. ARDS was associated with an increase in mortality, longer duration of mechanical ventilation, and longer ICU length of stay. In a cohort of brain-injured patients the development of ARDS was not common. Driving pressure was associated with the development of this disease.

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