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CLINICAL SIGNIFICANCE OF SOLUBLE SERUM FAS AND APO1/FAS GENE POLYMORPHISM (RS1800682) -670A>G IN SYSTEMIC LUPUS ERYTHEMATOSUS.

2016; Volume: 4; Issue: 11 Linguagem: Inglês

10.21474/ijar01/2111

2320-5407

RaghdaM. Mohammed, SamiaM. Hassan, EnasA. Abdelaleem, RababA. Mohamed,

Lipid metabolism and disorders

Systemic lupus erythematosus (SLE) is a complex genetically autoimmune disease with poorly understood pathogenesis.Lupus nephritis ( LN) is one of the most serious complications of SLE.Abnormalities of apoptosis may be involved in the development of autoimmune disorders Abnormal FAS-mediated apoptosis is one of the susceptibility factors in development of SLE.Promoter variants in the APO-1/Fas gene have been studied in SLE and other autoimmune diseases.Aim:The present case control study was conducted to detect the possible association APO1/FAS-670A>G gene polymorphism with susceptibility to SLE andLupus nephritis (LN)and detect an association between the SNP and disease activity.In addition, investigate the possible relation between the polymorphism and s FAS levels and their possible association with of lupus nephritis..Patients and Methods: fiftySLEpatients and 44 healthy control subjects were included in the study.SFas levels were detected by ELISA.PCR-RFLP was used to detect APO1/FAS-670A>G gene polymorphism.Lupus nephritis patients had proteinuria higher than 0.5g/24 hours .SLEDAI score was used to assess disease activity status in SLE and LN patients.Results:SFas levels were significantly higher in SLE compared to healthy control subjects (P G gene polymorphism was significantly higher in SLE patients compared to control group (P=0.029).There was a non-significant association between APO1/FAS-670A>G gene polymorphism and LN patients (P=0.326).There was a statistically significant positive correlation between sFas levels and SLEDAI score in patients carrying the AG genotype.Conclusion: Our results suggests a possible genetic association between increased risk of SLE and APO1/FAS-670A>G gene polymorphism.inaddition we suggest a possible relation between sFas levels and SLE activity status.