Prognostic Impact of Tumor Infiltrating FOXP3 Positive Regulatory T Cells in Diffuse Large B-Cell Lymphoma at Diagnosis.
2007; Elsevier BV; Volume: 110; Issue: 11 Linguagem: Inglês
10.1182/blood.v110.11.1565.1565
ISSN1528-0020
AutoresJae‐Yong Kwak, Na‐Ri Lee, Eun‐Kee Song, Kyu Yun Jang, Ha Na Choi, Woo Sung Moon, Keun-Sang Kwon, Ju Hyung Lee, Chang‐Yeol Yim,
Tópico(s)Immune Cell Function and Interaction
ResumoAbstract Tumor infiltrating immune cells play an important role in host immune reactions against diffuse large B-cell lymphoma (DLBCL). In the present study, we have identified a subset of tumor infiltrating FOXP3-positive regulatory T cells (Tregs) in the initial DLBCL biopsy specimens and evaluated its prognostic significance. Ninety-six patients with DLBCL were retrospectively evaluated. Expression pattern of FOXP3 protein was examined using standard immunohistochemistry in paraffin-embedded tissue samples. The median overall survival (OS) was 28 months. Compared to the others, the patients with higher percentage of FOXP3-positive Tregs in the initial tumor biopsy, showed a significantly longer OS (p=0.003). When prognostic factors were evaluated in a multivariate model, the international prognostic index and the percentage of infiltrating FOXP3-positive Tregs in the initial biopsy were shown to be independent predictors of OS. In conclusion, the presence of increased percentage of FOXP3-positive Tregs in DLBCL predicts a better prognosis. Figure Figure
Referência(s)