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Waterborne aripiprazole blunts the stress response in zebrafish

2016; Nature Portfolio; Volume: 6; Issue: 1 Linguagem: Inglês

10.1038/srep37612

2045-2322

Heloísa Helena de Alcântara Barcellos, Fabiana Kalichak, João Gabriel Santos da Rosa, Thiago Acosta Oliveira, Gessi Koakoski, Renan Idalêncio, Murilo S. de Abreu, Ana C.V.V. Giacomini, Michele Fagundes, Cristiane Variani, Mainara Rossini, Ângelo Piato, Leonardo José Gil Barcellos,

Neuroinflammation and Neurodegeneration Mechanisms

Abstract Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.