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A trial of unrelated donor marrow transplantation for children with severe sickle cell disease

2016; Elsevier BV; Volume: 128; Issue: 21 Linguagem: Inglês

10.1182/blood-2016-05-715870

1528-0020

Shalini Shenoy, Mary Eapen, Julie A. Panepinto, Brent R. Logan, Juan Wu, Allistair Abraham, Joel A. Brochstein, Sonali Chaudhury, Kamar Godder, Ann E. Haight, Kimberly A. Kasow, Kathryn Leung, Martin Andreánsky, Monica Bhatia, Jignesh Dalal, Hilary Haines, Jennifer Jaroscak, Hillard M. Lazarus, John E. Levine, Lakshmanan Krishnamurti, David M. Margolis, Gail Megason, Lolie C. Yu, Michael A. Pulsipher, Iris D. Gersten, Nancy DiFronzo, Mary M. Horowitz, Mark C. Walters, Naynesh Kamani,

Bone and Joint Diseases

Key Points Children with sickle cell disease engrafted unrelated donor marrow after reduced intensity conditioning. A high incidence of GVHD and associated mortality compromised safety of the trial.