Produção Nacional
Revisado por pares
Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats
2016; Elsevier BV; Volume: 91; Linguagem: Inglês
10.1016/j.foodres.2016.11.019
ISSN1873-7145
AutoresFernando Freitas de Lima, Giseli Karenina Traesel, Sara Emília Lima Tolouei, Ariany Carvalho dos Santos, Roosevelt Isaías Carvalho Souza, Vinícius Soares de Oliveira, Eliana Janet Sanjinez‐Argandoña, Cláudia Andréa Lima Cardoso, Silvia Aparecida Oesterreich, Maria do Carmo Vieira,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoAttalea phalerata Mart. ex Spreng., popularly known as "bacuri", is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000 mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000 mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000 mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans.
Referência(s)