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Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

2016; National Academy of Sciences; Volume: 113; Issue: 50 Linguagem: Inglês

10.1073/pnas.1617460113

1091-6490

Tze Guan Tan, Esen Sefik, Naama Geva‐Zatorsky, Lindsay Kua, Debdut Naskar, Fei Teng, Lesley Pasman, Adriana Ortiz-Lopez, Ray Jupp, Hsin-Jung Wu, Dennis L. Kasper, Christophe Benoist, Diane Mathis,

Probiotics and Fermented Foods

Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here, we identified human symbiont bacterial species, in particular Bifidobacterium adolescentis, that could, alone, induce Th17 cells in the murine intestine. Similar to SFB, B. adolescentis was closely associated with the gut epithelium and engendered cognate Th17 cells without attendant inflammation. However, B. adolescentis elicited a transcriptional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th17 cell accumulation. Inoculation of mice with B. adolescentis exacerbated autoimmune arthritis in the K/BxN mouse model. Several off-the-shelf probiotic preparations that include Bifidobacterium strains also drove intestinal Th17 cell accumulation.