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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

2016; American Association for the Advancement of Science; Volume: 354; Issue: 6313 Linguagem: Inglês

10.1126/science.aaf8156

1095-9203

Josephine M. Bryant, Dorothy Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter H. Gilligan, Charles R. Esther, Peadar G. Noone, Olivia Giddings, Scott C. Bell, Rachel Thomson, Claire Wainwright, Chris Coulter, Sushil Pandey, Michelle Wood, Rebecca E. Stockwell, Kay A. Ramsay, L. Sherrard, Timothy J. Kidd, Nassib Jabbour, Graham Johnson, Luke D. Knibbs, Lidia Morawska, Peter D. Sly, Andrew Jones, Diana Bilton, Ian F. Laurenson, Michael Ruddy, Stephen Bourke, I.C.J.W. Bowler, S. Jonathan Chapman, Andrew Clayton, M. Cullen, Owen Dempsey, Miles Denton, Maya Desai, Richard J. Drew, F. Edenborough, J. C. Evans, Jonathan Folb, T. Daniels, Helen Humphrey, B. Isalska, Søren Jensen‐Fangel, Bodil Jönsson, Andrew Jones, Terese L. Katzenstein, Troels Lillebæk, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, E.F. Nash, Christopher J. O’Brien, Deirdre O’Brien, Chandra Ohri, C. Pao, D. Peckham, Felicity Perrin, Audrey Perry, T. Pressler, Laura Prtak, Tavs Qvist, A. Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, N. West, J.L. Whitehouse, Charles Haworth, Simon R. Harris, Diane Ordway, Julian Parkhill, R. Andres Floto,

Gut microbiota and health

Global spread of aggressive mycobacteria Many mycobacteria, in addition to those causing leprosy and tuberculosis, are capable of infecting humans. Some can be particularly dangerous in patients suffering from immunosuppression or chronic disease, such as cystic fibrosis (CF). Bryant et al. observed clusters of near-identical isolates of drug-resistant Mycobacterium abscessus in patients reporting to CF clinics. The similarity of the isolates suggests transmission between patients, rather than environmental acquisition. Although this bacterium is renowned for its environmental resilience, the mechanism for its long-distance transmission among the global CF patient community remains a puzzle. Science , this issue p. 751